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10.1146/annurev-pathol-012615-044224 [DOI] [PubMed] [Google Scholar] Harjumaki R, Pridgeon CS, Ingelman-Sundberg M (2021) CYP2E1 in alcoholic and non-alcoholic liver injury roles of ROS reactive intermediates and lipid overload

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So we already know in case studies, and I think clinical research will prove this out over time, that there is a profound effect on the immune system